Aldehyde–alkyne–amine (A3) coupling catalyzed by a highly efficient dicopper complex
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A dicopper(I) complex, CuI 2ðpipÞ 2 (pip ¼ (2-picolyliminomethyl)pyrrole anion), was utilized to catalyze A3 coupling reactions, which led to the formation of propargylamines. Aldehydes, alkynes and amines with a variety of structures have been tested. A low catalyst loading of 0.4 mol% was sufficient to give good to excellent yields. The low catalyst loading, broad scope of substrate and easy preparation make this dicopper complex a useful catalyst for A3 coupling.