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dc.contributor.advisorMitra, Kunal
dc.contributor.authorKharel, Prabhuti
dc.date.accessioned2019-07-18T18:52:22Z
dc.date.available2019-07-18T18:52:22Z
dc.date.created2019-07
dc.date.issued2019-06-14
dc.date.submittedJuly 2019
dc.identifier.urihttp://hdl.handle.net/11141/2863
dc.descriptionThesis (M.S.) - Florida Institute of Technology, 2019en_US
dc.description.abstractBioprinting is a technique of creating 3D cell laden structures by accurately dispensing biomaterial to form complex synthetic tissue. Bioprinting is a process of additive manufacturing where the cell functionality and viability is preserved within the printed structure. Bioprinting is a promising alternative to produce physiologically relevant 3D structures that mimic the native tissue. However, fabrication of complex structures with vascularization has been a major challenge in bioprinting. To overcome this challenge sacrificial printing in combination with fugitive inks has been explored to create vascularize structures. The objective of this study is to fabricate hollow channels within the bioprinted structure for vascularization using sacrificial printing. The study explores optimization of alginate-gelatin hydrogel blends of different ratios to investigate the optimal alginate-gelatin mixture for bioprinting of perfusable constructs. Mechanical properties of different concentrations of alginate-gelatin blends are examined through rheology and compression studies. Printability tests are also performed to identify structural properties and accurate deposition of the alginate-gelatin blend hydrogels. Furthermore, three different vascular architecture models of varying complexities are explored to investigate the effect of architecture and surface geometry on stiffness and cell viability.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.subjectTissue engineeringen_US
dc.subjectBioprintingen_US
dc.subjectSacrifical printingen_US
dc.subjectPerfusable structuresen_US
dc.titleBioprinting of 3D Perfusable Structures Using an Extrusion-Based Systemen_US
dc.typeThesisen_US
dc.date.updated2019-07-01T17:32:18Z
thesis.degree.nameMastersen_US
thesis.degree.levelMastersen_US
thesis.degree.departmentBiomedical Engineeringen_US
thesis.degree.grantorFlorida Institute of Technologyen_US
dc.type.materialtext


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