Browsing College of Engineering and Science by Author "Xu, Shaohua"
Now showing items 1-7 of 7
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DETERMINING THE ROLE OF HUMAN PLASMA IN AMYLOID FIBER SYNTHESIS
Confer, Carlee Renee (2019-12)The presence of plaques and tangles in the human brain is a major feature observed in several neuropathological diseases including Parkinson’s and Alzheimer’s. Due to the high morbidity and mortality rates of such diseases, ... -
Gel formation in protein amyloid aggregation: A physical mechanism for cytotoxicity
Burnett, Lisa Cole; Woodard, Daniel; Bell, Dylan; Tipton, David A.; Durrance, Samuel; Li, Bin; Xu, Shaohua (2014-04-16)Amyloid fibers are associated with disease but have little chemical reactivity. We investigated the formation and structure of amyloids to identify potential mechanisms for their pathogenic effects. We incubated lysozyme ... -
Mass Spectrometry Analysis of Fatty Acid Binding to Albumin
Nascimento, CarolinaAlbumin is responsible for the transportation of numerous amphipathic molecules including fatty acids in our blood. The number of fatty acids bound to each albumin fluctuates under physiologic and pathologic conditions ... -
RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes
Palavicini, Juan Pablo; Wang, Hongjie; Bianchi, Elisabetta; Xu, Shaohua; Rao, Jagadeesh S.; Kang, David E.; Lakshmana, Madepalli K. (2013-06)We previously demonstrated that over expression of RanBP9 led to enhanced Ab generation in a variety of cell lines and primary neuronal cultures, and subsequently, we confirmed increased amyloid plaque burden in a mouse ... -
RanBP9 overexpression accelerates loss of pre and postsynaptic proteins in the APΔE9 transgenic mouse brain
Wang, Hongjie; Wang, Ruizhi; Xu, Shaohua; Lakshmana, Madepalli Krishnappa (2014-01-14)There is now compelling evidence that the neurodegenerative process in Alzheimer's disease (AD) begins in synapses. Loss of synaptic proteins and functional synapses in the amyloid precursor protein (APP) transgenic mouse ... -
The Roles of Diffusion and Bulk Flow in Neural Function and Alzheimer's Disease
Dauberman, Wade N. (2017-07)Alzheimer’s disease (AD) is a neurodegenerative disorder affecting close to 5.1 million Americans and its incidence is expected to rise with the higher number of people in the aging population. A hallmark of the disease ... -
Techniques to quantify the size of protein colloids in amyloid fiber formation
Anson, Jonathan R.; Lu, Chia-Hung; Cui, Lingwen; Yang, Xiaojing; Xu, Shaohua (2013-01)A new method for the analysis of protein colloidal diameter has been developed using three existing protein concentration quantification techniques, absorption at 280 nm, colloidal gold assay, and DC protein assay. Protein ...