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dc.contributor.authorUsselman, Robert J.
dc.contributor.authorChavarriaga, Cristina
dc.contributor.authorCastello, Pablo R.
dc.contributor.authorProcopio, Maria
dc.contributor.authorRitz, Thorsten
dc.contributor.authorDratz, Edward A.
dc.contributor.authorSingel, David John
dc.contributor.authorMartino, Carlos F.
dc.date.accessioned2018-01-09T17:31:09Z
dc.date.available2018-01-09T17:31:09Z
dc.date.issued2016-12-20
dc.identifier.citationUsselman, R. J., Chavarriaga, C., Castello, P. R., Procopio, M., Ritz, T., Dratz, E. A., . . . Martino, C. F. (2016). The quantum biology of reactive oxygen species partitioning impacts cellular bioenergetics. Scientific Reports, 6en_US
dc.identifier.urihttp://hdl.handle.net/11141/2263
dc.description.abstractQuantum biology is the study of quantum effects on biochemical mechanisms and biological function. We show that the biological production of reactive oxygen species (ROS) in live cells can be influenced by coherent electron spin dynamics, providing a new example of quantum biology in cellular regulation. ROS partitioning appears to be mediated during the activation of molecular oxygen (O2) by reduced flavoenzymes, forming spin-correlated radical pairs (RPs). We find that oscillating magnetic fields at Zeeman resonance alter relative yields of cellular superoxide (O2•−) and hydrogen peroxide (H2O2) ROS products, indicating coherent singlet-triplet mixing at the point of ROS formation. Furthermore, the orientation-dependence of magnetic stimulation, which leads to specific changes in ROS levels, increases either mitochondrial respiration and glycolysis rates. Our results reveal quantum effects in live cell cultures that bridge atomic and cellular levels by connecting ROS partitioning to cellular bioenergetics.en_US
dc.language.isoen_USen_US
dc.rights© Usselman, Robert J., Chavarriaga, Cristina, Castello, Pablo R., Procopio, Maria, Ritz, Thorsten, Dratz, Edward A., Singel, David John, Martino, Carlos F 2016.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleThe Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergeticsen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep38543


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© Usselman, Robert J., Chavarriaga, Cristina, Castello, Pablo R., Procopio, Maria, Ritz, Thorsten, Dratz, Edward A., Singel, David John, Martino, Carlos F 2016.
Except where otherwise noted, this item's license is described as © Usselman, Robert J., Chavarriaga, Cristina, Castello, Pablo R., Procopio, Maria, Ritz, Thorsten, Dratz, Edward A., Singel, David John, Martino, Carlos F 2016.