Show simple item record

dc.contributor.authorFarkash-Amar, Shlomit
dc.contributor.authorLipson, Doron
dc.contributor.authorPolten, Andreas
dc.contributor.authorGoren, Alon
dc.contributor.authorHelmstetter, Charles
dc.contributor.authorYakhini, Zohar
dc.contributor.authorSimon, Itamar
dc.date.accessioned2017-12-08T00:53:14Z
dc.date.available2017-12-08T00:53:14Z
dc.date.issued2008-10
dc.identifier.citationFarkash-Amar, S., Lipson, D., Polten, A., Goren, A., Helmstetter, C., Yakhini, Z., Simon, I. Global organization of replication time zones of the mouse genome (2008) Genome Research, 18 (10), pp. 1562-1570. Cited 107 times.en_US
dc.identifier.urihttp://hdl.handle.net/11141/2217
dc.descriptiongenomic DNA, animal cellen_US
dc.description.abstractThe division of genomes into distinct replication time zones has long been established. However, an in-depth understanding of their organization and their relationship to transcription is incomplete. Taking advantage of a novel synchronization method ("baby machine") and of genomic DNA microarrays, we have, for the first time, mapped replication times of the entire mouse genome at a high temporal resolution. Our data revealed that although most of the genome has a distinct time of replication either early, middle, or late S phase, a significant portion of the genome is replicated asynchronously. Analysis of the replication map revealed the genomic scale organization of the replication time zones. We found that the genomic regions between early and late replication time zones often consist of extremely large replicons. Analysis of the relationship between replication and transcription revealed that early replication is frequently correlated with the transcription potential of a gene and not necessarily with its actual transcriptional activity. These findings, along with the strong conservation found between replication timing in human and mouse genomes, emphasize the importance of replication timing in transcription regulation. ©2008 by Cold Spring Harbor Laboratory Press.en_US
dc.language.isoen_USen_US
dc.rightsCopyright © 2008, Cold Spring Harbor Laboratory Pressen_US
dc.rights.urihttp://genome.cshlp.org/site/misc/open_access.xhtmlen_US
dc.titleGlobal organization of replication time zones of the mouse genome.en_US
dc.typeArticleen_US
dc.identifier.doi10.1101/gr.079566.108


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record