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dc.contributor.authorKwan, James
dc.contributor.authorKaya, Mehmet
dc.contributor.authorBorden, Mark A.
dc.contributor.authorDayton, Paul Alexander
dc.date.accessioned2017-12-05T22:04:31Z
dc.date.available2017-12-05T22:04:31Z
dc.date.issued2012
dc.identifier.citationKwan, J. J., Kaya, M., Borden, M. A., & Dayton, P. A. (2012). Theranostic oxygen delivery using ultrasound and microbubbles. Theranostics, 2(12), 1174-1184en_US
dc.identifier.urihttp://hdl.handle.net/11141/2203
dc.descriptionHypoxia, Oxidation, Oxygenation, Radiotherapy, Tumoren_US
dc.description.abstractMeans to overcome tumor hypoxia have been the subject of clinical investigations since the 1960's; however these studies have yet to find a treatment which is widely accepted. It has been known for nearly a century that hypoxic cells are more resistant to radiotherapy than aerobic cells, and tumor hypoxia is a major factor leading to the resistance of tumors to radiation treatment as well as several cytotoxic agents. In this manuscript, the application of ultrasound combined with oxygen-carrier microbubbles is demonstrated as a method to locally increase dissolved oxygen. Microbubbles can also be imaged by ultrasound, thus providing the opportunity for image-guided oxygen delivery. Simulations of gas diffusion and microbubble gas exchange show that small amounts (down to 5 vol%) of a low-solubility osmotic gas can substantially increase microbubble persistence and therefore production rates and stability of oxygen-carrier microbubbles. Simulations also indicate that the lipid shell can be engineered with long-chain lipids to increase oxygen payload during in vivo transit. Experimental results demonstrate that the application of ultrasound to destroy the microbubbles significantly enhances the local oxygen release. We propose this technology as an application for ultrasound image-guided release of oxygen directly to hypoxic tissue, such as tumor sites to enhance radiotherapy.en_US
dc.language.isoen_USen_US
dc.rights© 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.en_US
dc.rights.urihttp://creativecommons.org/ licenses/by-nc-nd/3.0/en_US
dc.titleTheranostic oxygen delivery using ultrasound and microbubblesen_US
dc.typeArticleen_US
dc.identifier.doi10.7150/thno.4410


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© 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
Except where otherwise noted, this item's license is described as © 2012 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.