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Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice ( Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, ...
Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness
Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical ...
Effects of normal and abnormal loading conditions on morphogenesis of the prenatal hip joint: application to hip dysplasia
Joint morphogenesis is an important phase of prenatal joint development during which the opposing cartilaginous rudiments acquire their reciprocal and interlocking shapes. At an early stage of development, the prenatal hip ...
Animal models of osteogenesis imperfecta: Applications in clinical research
Osteogenesis imperfecta (OI), commonly known as brittle bone disease, is a genetic disease characterized by extreme bone fragility and consequent skeletal deformities. This connective tissue disorder is caused by mutations ...