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dc.contributor.advisorKnight, D. A.
dc.contributor.authorFaylough, Samira M
dc.date.accessioned2017-06-06T14:36:22Z
dc.date.available2017-06-06T14:36:22Z
dc.date.issued2017-05
dc.identifier.urihttp://hdl.handle.net/11141/1466
dc.descriptionThesis (Ph.D.) - Florida Institute of Technology, 2017en_US
dc.description.abstractVanadium compounds are known to play many roles in both biology and industry, and the biochemical activity of these compounds has led to their increased importance in both biological and medical research. In the present work, some new substituents for hydrazinecarbodithioate Schiff base ligands and their dioxo vanadium(V) complexes were synthesized and characterized by ¹H NMR, ¹³C NMR, DART mass, FT-IR, UV-vis, fluorescence spectrometer, and single X-ray diffraction analysis for complex K[VO₂{(S-benzyl-3-(2-hydroxy-5-nitrophenyl) methylene dithiocarbazate)}] (212). Dioxovanadium(V) complexes K[VO₂{(S-methyl-3-(2-hydroxy-5-nitrophenyl)methylenedithiocarbazate)}] (211) and 212 have been tested for antibacterial activity against Burkholderia pseudomallei and Burkholderia mallei strains. Ceftazidime was used as a reference in this study. Complex 212.has been shown to have higher antibacterial activity compared to complex 211. In some strains the minimum inhibitory concentration (MIC) values of complex 212 are only 2-fold higher than Ceftazidime and the antibacterial activity of this complex against B. pseudo is stronger than it is against B. mallei. Based on these results, we synthesized some hydrazine carbodi- thioate Schiff base ligands which have derivatives of the benzyl group to test their antibacterial ability against B. pseudomallei and B. mallei strains. The ligands 203, 204, and 205 show a stronger intensity of fluorescence in comparison with their complexes 213, 214, and 215, respectively. The fluorescent properties of vanadium complexes allow them to be used as cellular imaging agents in living cells.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.rightsCopyright held by author.en_US
dc.titlePart (I): Synthesis, Characterization and Antibacterial Activity of Vanadium(V) Complexes with ONS Schiff bases Part (II): Synthesis of 9-CD₃-11-cis-Retinal for the Investigation of the Activation Mechanism of GPCR Rhodopsin by Solid-State ²H NMR Spectroscopyen_US
dc.typeDissertationen_US
dc.date.updated2017-05-11T14:59:30Z
thesis.degree.nameDoctor of Philosophy in Chemistryen_US
thesis.degree.levelDoctoralen_US
thesis.degree.disciplineChemistryen_US
thesis.degree.departmentChemistryen_US
thesis.degree.grantorFlorida Institute of Technologyen_US
dc.type.materialtext


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