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dc.contributor.authorPal, Gopalendu
dc.contributor.authorMitra, Kunal
dc.contributor.authorVo- Dinh, Tuan
dc.date.accessioned2017-05-22T20:43:09Z
dc.date.available2017-05-22T20:43:09Z
dc.date.issued2006-02-25
dc.identifier.citationPal, G., Mitra, K., & Vo-Dinh, T. (2006). Short-pulse laser propagation through tissue medium for tumor detection. Paper presented at the Proceedings of SPIE - the International Society for Optical Engineering, 6080 doi:10.1117/12.664121en_US
dc.identifier.urihttp://hdl.handle.net/11141/1445
dc.description.abstractThe objective of this paper is to perform a comprehensive experimental and numerical analysis of the short pulse laser interaction with tissue medium with the goal of tumor / cancer diagnostics. For short pulse laser source, the shape of output signal is a function of the optical properties of the medium and hence the scattered temporal optical signal helps in understanding of the medium characteristics. Initially experiments are performed on tissue phantoms imbedded with inhomogeneities in order to optimize the time-resolved optical detection scheme. Both the temporal and the spatial profiles of the scattered reflected and transmitted optical signals are compared with the numerical modeling results obtained by solving the transient radiative transport equation using the discrete ordinates technique. Next experiments are performed on in vitro rat tissue samples to characterize the interaction of light with skin layers and to validate the time varying optical signatures with the numerical model. The numerical modeling results and the experimental measurements are in excellent agreement for the different parameters studied in this paper. The final step is to perform in vivo imaging of anaesthetized rats with tumor-promoting agents injected inside skin tissues in order to demonstrate the feasibility of the technique in detecting tumors in animal model.en_US
dc.language.isoen_USen_US
dc.rightsThis published article is made available in accordance with publishers policy. It may be subject to U.S. copyright law.en_US
dc.rights.urihttp://spie.org/publications/journals/guidelines-for-authors#Terms_of_Useen_US
dc.titleShort-pulse laser propagation through tissue medium for tumor detectionen_US
dc.typeConference Proceedingen_US
dc.identifier.doi10.1117/12.664121


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