Browsing by Author "Oldknow, Karla J."

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Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing

Javaheri, Behzad; Carriero, Alessandra; Staines, Katherine Ann Nn; Chang, Y. M.; Houston, D. A.; Oldknow, Karla J.; Millán, José Luis; Kazeruni, Bassir N.; Salmon, Phil L.; Shefelbine, Sandra J. (2015-12-01)

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice ( Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, ...
Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness

Carriero, Alessandra; Bruse, Jan L.; Oldknow, Karla J.; Millán, José Luis; Farquharson, Colin; Shefelbine, Sandra J. (2014-10-14)

Bone fragility is a concern for aged and diseased bone. Measuring bone toughness and understanding fracture properties of the bone are critical for predicting fracture risk associated with age and disease and for preclinical ...