Browsing by Author "Nakamura, Hiroyuki"

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Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity

Poulet, Blandine; Liu, Ke; Plumb, Darren A.; Vo, Phoung; Shah, Mittal; Staines, Katherine Ann; Sampson, Alexandra; Nakamura, Hiroyuki; Nagase, Hideaki; Carriero, Alessandra (2016-12-21)

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and ...